SFI Health

Ivy Leaf (Hedera helix EA 575)

Preparations from ivy leaf, or Hedera helix as it is known botanically, are well established for the relief of productive or chesty coughs.


In the Flordis Prospan range, a specific extract from the leaves of Hedera helix is used, called EA 575®. This extract is carefully obtained through a patented extraction process that helps ensure a consistent composition of ingredients. This is critical because it’s this specific extract EA 575 that’s been the subject of extensive clinical research ­– showing five action chesty cough relief in thousands of patients, both children and adults.1-8


Discover more about the exclusive EA 575 extract used in Flordis Prospan.

Hedera helix in history

Hedera helix is a climbing evergreen plant that is native to most of Europe and northern and central Asia. It’s a familiar garden plant to many people, and bears an association with the festivities of Christmas since Roman times. It was also a symbol of fidelity in Ancient Greece, presented to newlyweds. 

Historically it was used for a wide array of applications including digestive issues and general wounds. Nowadays it is a widely used natural remedy with well-established medicinal use for chesty cough symptoms.11

Hedera helix in history

The specific Ivy leaf extract used in Prospan range: EA 575®

EA 575® is the specific extract of Hedera helix used in the Flordis Prospan range, and was developed over 65 years ago based on extensive research and expertise. The EA 575 extract, produced by a patented extraction process, is distinct from other Ivy leaf extracts. It has been researched in clinical trials, observational and scientific studies around the world.1

The studies cover a huge number of participants – more than 65,000 patients – and show reliable relief of chesty cough symptoms with Prospan products containing this exclusive extract. 1

It is important to acknowledge that these results apply exclusively to products containing the EA 575 extract, which is made using a patented production process to ensure a consistently high quality medicine from batch to batch – the same reliable medicine tested in numerous clinical trials to provide chesty cough relief.  


The production process of EA 575 is of great importance, as demonstrated below.12


EA 575 Ivy leaf production process


Careful attention is paid at every step of creation to help ensure a consistently high-quality product from one batch to the next.


The health benefits of EA 575 are based on numerous clinical studies in adults and children*. Results from these clinical studies demonstrate that EA 575 helps to:1-10


  • Thin and loosen mucus so it is easier to clear from the airways
  • Clear stubborn chest congestion allowing you to cough more productively
  • Soothe and relax the airways to allow more airflow into the lungs and ease breathing
  • Calm the chest
  • Relieve inflammation

*Check with your healthcare professional if Prospan products are right for you. Always see a doctor if you suspect a more serious condition, or if symptoms or coughing persist.

The specific Ivy leaf extract used in Prospan range: EA 575®

Research on how EA 575 works

Evidence suggests that Prospan works to relieve the symptoms of a chesty cough in five different ways.9,10

Five action formula of EA 575 


  1. Thins and loosens mucus so it is easier to clear from the airways
  2. Clears stubborn chest congestion allowing you to cough more productively
  3. Soothes and relaxes the airways to allow more airflow into the lungs and ease breathing
  4. Calms the chest
  5. Relieves inflammation
Research on how EA 575 works

EA 575® in Prospan: Clinical studies

EA 575® has been investigated in numerous research publications, including clinical trials and observational studies, involving more than 65,000 patients.1

Lang et al., 20152

1066 school children
(aged 6–12 years)
studied over 1 week


of cough, expectoration, breathing symptoms due to a cold.

  • Additionally: improvement in symptoms was demonstrated after as little as 3.48 days

Study included Prospan, Prospan Drops and Prospan lozenges.*

Fazio et al., 2009 3

9657 patients
(aged 0-98 years*) 
studied over 7 days


  • Cough (93% of patients)
  • Clearance of chest mucus due to a cold (93% of patients)
  • Soothe and calming the chest (91% of patients)
  • Good or very good tolerability (97% of patients)

Study included Prospan.*

Schaefer et al., 2016 4

181 adults with acute cough (aged 18–75 years)
studied over 7 days

Significant improvement

vs. placebo for:

  • Cough severity over period of 7 days Relief within 48 hours

Study included Prospan Menthol.*

Bolbot et al., 2004 5

50 children
(2-10 years of age)
studied over 7–10 days

Significant improvement

  • Breathing symptoms due to a cold

Additionally : 96% of patients rated efficacy of Prospan 'good' or 'very good' and tolerability of Prospan rated as 'good' or 'very good' in 100% of patients

Study included Prospan.*

Kraft et al., 2004 6

52,478 children
(up to 12 years of age)

Retrospective survey confirmation

  • very good tolerability in a large group of patients

Study included Prospan.*

*Prospan and Prospan for Children are not to be used in children under 2 years without medical advice. Prospan Menthol and lozenges are not to be given to children under 6 years. Prospan Drops are not to be given to children under 12 years. These medicines may not be right for you. Read the warnings before purchase. These can be found in the dosage sections of the Prospan product web pages.  Follow the directions for use. If symptoms or coughing persist, talk to your health professional.

Flordis Difference

EA 575 vs. Hedera helix – The Prospan difference

Products with naturally sourced active ingredients can vary considerably depending on how they are produced. The specific EA 575 extract used in the Prospan range is produced using a rigorous and controlled process with careful consideration at every stage of creation. 


This helps to ensure the Prospan with EA 575  you are getting is high quality with a consistent amount and composition of active ingredient, consistently reliable, and the same as the medicine researched in clinical studies to deliver chesty cough relief.1

Prospan with EA 575: A Summary

Consistent quality

Rigorous processes, quality controls and extensive testing ensures that Prospan with  EA 575 can provide the desired health outcomes demonstrated in clinical studies.1

Over 65 years of research & development

Investigating the beneficial effect of Prospan with exclusive ivy leaf extract (EA 575) in patients with chesty coughs.1

20 research publications

Support the role of Prospan with EA 575 in relieving the symptoms of a chesty cough.3

World’s No. 1 selling ivy leaf product

Recommended and used by millions of people worldwide for reliable chesty cough relief. 13

  1. Lang C, et al., Planta Med 2015;81:968-974. Supported by Engelhard Arzneimittel GmbH & Co. KG. 
  2. Lang C, et al., Zeitschrift für Phytotherapie 2015;36:192-196. Supported by Engelhard Arzneimittel GmbH & Co. KG. 
  3. Fazio S, et al., Phytomedicine 2009;16.1:17-24.
  4. Schaefer A, et al., Pharmazie 2016;71(9):504-509. Supported by Engelhard Arzneimittel GmbH & Co. KG. 
  5. Bolbot Y, et al., Drugs of Ukraine 2004;11:1-4.
  6. Kraft K. Zeitschrift für Phytotherapie 2004;25:179-181.
  7. Maidannik V, et al., Pediatrics, Tocology and Gynecology 2003;4:1-7.
  8. Meyer-Wegener, J et al., Zeitschrift für Allgemeinmedizin 1993;69:61-66.
  9. Schlenger R. Deutsche Apotheker Zeitung 2003;143(49) [translation].
  10. Runkel F, et al., Pharmazeutische Zeitung 2005;15.04:19-25.
  11. European Medicines Agency, Committee on Herbal Medicinal Products, EU  herbal monograph on Hedera helix. Retrieved from link.
  12. Gaedcke F. Deutsche Apotheker Zeitung 1991;131:2251-2255.
  13. IMS MIDAS data, Absatz MAT04/2019. 


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